Hematology Infectious diseases Inflammatory diseases Kidney diseases. Liver diseases Metabolic disorders Rheumatology Urinalysis. Blood test. What is a low MPV called? What is the normal level of MPV in the blood? What does a low MPV in a blood test mean? Which factors can reduce the MPV? Which diseases can reduce your MPV?
What can I do to increase the MPV level in the blood? Which values are considered a low MPV level in the blood? A low MPV may be due to: If the platelet count is lower than normal: Aplastic anemia or chemotherapy drugs. If the platelet count is in normal range: Kidney failure. If the platelet count is high: An infection, inflammation or any type cancer.
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Anticoagulants and antiplatelet drugs are a type of medication that is used to eliminate or reduce the risk of blood clots by helping prevent or break…. Health Conditions Discover Plan Connect. Medically reviewed by Debra Sullivan, Ph. Testing process. High MPV meaning.
Low MPV meaning. The bottom line. Read this next. Hematocrit Test. Medically reviewed by Carissa Stephens, R. Blood Glucose Test. Causes shown below are commonly associated with low MPV. Work with your doctor or another health care professional to get an accurate diagnosis.
Some inflammatory diseases, such as rheumatoid arthritis, lupus, inflammatory bowel disease IBD , and familial Mediterranean fever have been associated with low MPV.
MPV usually increases with anti-inflammatory therapy [ 3 , 12 , 13 ]. Some conditions which impaired bone marrow function, such as aplastic anemia, are associated with low MPV. New platelets are not produced by the bone marrow, so older, smaller platelets make up a larger proportion of all the platelets in the bloodstream [ 14 , 15 ].
Drugs that kill cells or reduce their division, such as chemotherapy drugs, can decrease platelet production and MPV [ 15 , 14 ]. Some rare genetic clotting disorders have been associated with lower MPV [ 16 ]. A low MPV is usually caused by an underlying medical condition.
Alternatively, it can be low due to chemotherapy. MPV usually returns to normal once the underlying condition has been resolved. A high MPV means that platelets are larger than average.
Larger platelets are more reactive. This is sometimes a sign that the body is producing too many platelets [ 17 ]. However, a high MPV on its own is not informative enough and must be looked at in conjunction with other tests to diagnose platelet-associated conditions. Causes shown below are commonly associated with high MPV. A study with people found that lower blood vitamin D levels were associated with high MPV [ 18 ].
A study of obese and non-obese people suggests that obesity may be associated with significantly higher MPV. Other metabolic disorders that have been associated with higher MPV include high cholesterol, diabetes, and insulin resistance [ 20 , 21 , 22 ].
Both underactive and overactive thyroid hypo- or hyperthyroidism have been linked to higher MPV [ 23 , 24 ]. Idiopathic thrombocytopenic purpura ITP is an autoimmune disease in which antibodies attack platelets. Slow-growing blood cancers myeloproliferative disorders and various other cancers have been associated with higher MPV [ 14 , 26 , 27 , 28 ]. Chronic myeloid leukemia CML is a rare type of cancer of the blood cells.
Platelet production in this disease is abnormal and results in giant platelets. Some inherited genetic disorders can increase MPV. One of the most common such disorders is thalassemia, an inherited red blood cell disorder [ 14 , 30 , 31 , 32 , 33 , 34 ].
Several studies, each of a couple hundred people, suggest that smokers have higher MPV and that smoking cessation helps decrease it [ 35 , 36 , 37 ]. In a study of people with a suddenly reduced heart blood flow acute coronary syndrome , MPV on average was higher in people living at high altitudes [ 38 ]. Under certain conditions, platelets can be harmful, causing blood clots to form where they are not needed.
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